Sticky Nanoparticles: A Platform for siRNA Delivery by a Bis(zinc(II) dipicolylamine)-Functionalized, Self-Assembled Nanoconjugate
نویسندگان
چکیده
منابع مشابه
Molecularly self-assembled nucleic acid nanoparticles for targeted <i>in vivo</i> siRNA delivery
Nanoparticles are used for delivering therapeutics into cells1,2. However, size, shape, surface chemistry and the presentation of targeting ligands on the surface of nanoparticles can affect circulation half-life and biodistribution, cell-specific internalization, excretion, toxicity and efficacy3–7. A variety of materials have been explored for delivering small interfering RNAs (siRNAs)—a ther...
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Nanoparticles are used for delivering therapeutics into cells. However, size, shape, surface chemistry and the presentation of targeting ligands on the surface of nanoparticles can affect circulation half-life and biodistribution, cell-specific internalization, excretion, toxicity and efficacy. A variety of materials have been explored for delivering small interfering RNAs (siRNAs)--a therapeut...
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A number of diseases can result from abnormal gene expression. One of the approaches for treating such diseases is gene therapy to inhibit expression of a particular gene in a specific cell population by RNA interference. Use of efficient delivery vehicles increases the safety and success of gene therapy. Here we report the development of functionalized biocompatible fluorescent nanoparticles f...
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Intervention of the inflammation cascade with tumor necrosis factor-a (TNF-a) monoclonal antibodies or receptors represents a major approach in clinical immunotherapy against inflammatory diseases, which however, often suffers from high cost, autoimmunity to antibodies, and various side effects. siRNA-mediated RNA interference (RNAi) has recently emerged as a potent modality in regulating gene ...
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2011
ISSN: 0044-8249
DOI: 10.1002/ange.201105565